AI 神经代理框架用 fMRI 无创预测神经调控的认知效果

研究基于 Natural Scenes Dataset 4 名被试超过 36,000 条图像-fMRI 观测， subject-specific 模型的二选一识别率达 0.79-0.

88（随机为 0.5）。

在 VDVAE 模型中，效价从 -0.61 SD 移至 +1.

03 SD，记忆度从 -1.34 SD 移至 +1.

45 SD；18 名被试共 7,200 次人类评分中，16 人的效价朝预测方向变化。

自动化评分器与人类效价评分的相关仅为 r = 0.30，且极端扰动会导致图像偏离原始刺激。

AI-Driven Neural Surrogates for In Silico Design of Cognitive-Affective Neuromodulation Targets

In neuropsychiatry, the primary goal is often not only to decode brain activity but to change it, for example to lessen a negative affective bias or an overly salient memory. Motivated by control theory, we develop an AI-driven neural-surrogate framework that proposes candidate representational changes and tests their predicted perceptual effects from snapshots of stimulus-evoked fMRI activity, without physical stimulation. The framework combines fMRI decoding, deep generative modeling, and constrained latent-space steering. Valence and memorability are used only as worked examples. Using more than 36,000 image-fMRI observations from four deeply sampled Natural Scenes Dataset participants, subject-specific models recovered coarse generative structure from visually responsive cortex (two-way identification, 0.79-0.88; chance, 0.5). Graded perturbations were reconstructed as images and evaluated with automated scorers and human ratings from 7,200 trials by 18 participants. In the primary VDVAE model, valence shifted from -0.61 to +1.03 SD and memorability from -1.34 to +1.45 SD; a later Versatile Diffusion refinement reduced or altered these effects. Across five perturbation levels, human valence ratings moved in the predicted direction under the linear time-correction model (mean slope, 0.038 SD per unit of alpha; 95 percent CI, 0.003-0.074; positive in 16 of 18 participants). Perceived memorability did not change reliably. Baseline agreement with the automated assessor was suggestive for valence (r = 0.30) and weak for memorability (r = 0.10). Extreme perturbations drifted from the original stimulus, so intended change must be weighed against loss of fidelity. These findings provide a falsifiable upstream method for designing and behaviorally testing candidate representational targets for future neuromodulation in psychiatry, while marking the limits of the present static approximation.

本条情报归属 AITOP「论文」核心追踪栏目。在跨区域产业观察坐标中，该动态直接关联「AI 开发者工具链、Coding Agent 与工程化实践」研究主线，反映出当前技术演进与商业落地的最新风向。涉及核心实体与技术议题包括：fMRI、VDVAE、Neural Surrogates、神经调控，读者可通过下方标签进入对应专题页查阅历史脉络与关联对比。

信源核验说明：本文原始线索采编自「arXiv cs.AI」（@Marco Rothermel, Madleen Stenger, Soroush Daftarian, Svenja Jule Francke, Bita Shariatpanahi, José C. García Alanis, Mohammad-Ali Nikouei Mahani, Stefan G. Hofmann, Tim Hahn, Hamidreza Jamalabadi），经 AITOP 多维评分管线结构化提炼。