制药研发知识图谱模型提升文档检索准确率

在测试中，该模型在505个问题上的多选题准确率达到95%，显示出强大的平台可靠性。

From Document Silos to Process Intelligence: A Multi-Layer Knowledge Graph for CMC Process Development

Chemistry, Manufacturing and Controls (CMC) process development generates an enormous body of technical information across a multi-stage, knowledge-intensive continuum from drug discovery to commercial manufacturing. This knowledge is traditionally fragmented across functions and heterogeneous formats, causing traceability gaps and significant knowledge-management costs during technology transfer and regulatory filing. We present a modular agentic-AI platform that converts a heterogeneous corpus of process-development documents into a queryable, dual-layer knowledge graph. A base knowledge layer builds a lexical graph with a Document-Section-Chunk hierarchy through lossless ingestion of digital, scanned, handwritten, and multilingual documents, while an intelligence layer extracts ontology-aligned entities and bridges cross-document concepts through a provenance-anchored domain graph. LLM agents operate across both layers, selecting the retrieval path best suited to each question. We evaluate the lexical layer with a novel three-tier protocol measuring the deployment-fidelity of a retrieval-augmented generation (RAG) system on proprietary data, demonstrated on 505 questions curated from 38 development reports of a Sanofi small-molecule program. Tier-1 multiple-choice accuracy of 95% signals strong platform reliability; the stricter Tier-2 LLM-judge pass rate of 85%, which degrades on comparative and corpus-wide questions, reveals a failure taxonomy that Tier-1 accuracy alone fails to capture. A router agent selects between layers according to question type. We anticipate this protocol will enable future designers of agentic platforms to assess their systems against nonpublic databases, and that graph-based architectures will see broader adoption in pharma as a means of transforming fragmented document repositories into structured process intelligence.

本条情报归属 AITOP「论文」核心栏目，重点聚焦北美前沿实验室与硅谷科技巨头。在跨区域产业观察坐标中，该动态直接关联「AI 开发者工具链、Coding Agent 与工程化实践」研究主线，反映出当前技术演进与商业落地的最新风向。涉及核心实体与技术议题包括：RAG、知识图谱、制药、文档处理，读者可通过下方标签进入对应专题页查阅历史脉络与关联对比。

信源核验说明：本文原始线索采编自「arXiv cs.AI」（@Reza Amirmoshiri, Faryad Sahneh, Yasser Jangjou），经 AITOP 多维评分管线结构化提炼。