AIPOCH 开源 Open-Science：给科研 AI 工作流加上可溯源记录
科研党可以看看这个：开源的 Open-Science 把编程智能体接上 AlphaFold2、PubChem 这些工具，每个结果都能溯源重放，再也不怕问'这图怎么来的'。
AIPOCH 发布了开源的 Open-Science，一个 Apache-2.0 协议的桌面工作台，把 Claude Code、Codex、OpenCode 或 CodeBuddy 等编程智能体变成科研助手。它内置 AlphaFold2、ESM-2 等科学技能，可连接 PubChem、GTEx、cBioPortal 数据库。每次输出都以带校验和的不可变版本存储，Provenance 视图记录生成代码、输入、环境和执行历史，并支持隔离重放对比结果。会话可导出为 .science 包供协作者查验，项目默认保存在本地，也可通过 SSH 或 Slurm 提交到自有服务器。在 BiomniBench-DA 公开任务上，gpt-5.6-sol 得分 79.05，排名第一。
AI research with a paper trail, and it’s open source.
@aipoch_ai has released Open-Science, a free Apache-2.0 desktop workbench that turns coding agents into research assistants for scientists.
The problem is familiar to anyone using AI for analysis. You get a clean figure, then someone asks how it was made: which input, which code, which branch of the chat where an assumption changed. That context usually sits scattered across chats, notebooks and folders.
Open-Science keeps it in one place. You open a project, describe the goal, attach data, and the agent works through it with Python or R notebooks, scientific skills like AlphaFold2 and ESM-2, and connectors to databases such as PubChem, GTEx and cBioPortal. You choose how much it does alone, from approving every command to full access.
Each output is stored as an immutable, checksummed version, with a Provenance view showing the producing code, inputs, environment and execution history. A built-in replay can rerun that version from its sealed recipe in isolation and compare the new files against the originals. When you’re done, the session exports as a .science package a collaborator can import to inspect your branches, files and evidence.
Model choice stays open. Open-Science runs Claude Code, Codex, OpenCode or CodeBuddy as the agent engine, with cloud APIs, a local model through Ollama or vLLM, or your existing Claude or Codex subscription, and projects stay local by default. Bigger jobs can go to your own server over SSH or Slurm.
AIPOCH reports 79.05 with gpt-5.6-sol on BiomniBench-DA’s public tasks, ranking first in its comparison on a benchmark that grades agents on full biomedical analyses taken from published papers.
