Anthropic 用 Claude 首次解析细菌 vault 颗粒 3D 结构
Anthropic 的生命科学团队拿 Claude 解析了细菌 vault 蛋白的 3D 结构，原来要几周的活几天干完，还坦白了 AI 犯的错。
Anthropic 生物学研究团队与 Claude 合作，绘制出细菌 vault 颗粒的首个 3D 结构。vault 颗粒是 1986 年 Leonard Rome 和 Nancy Kedersha 发现的桶状大型蛋白结构，功能至今未知。此前 vault 只在动植物等复杂细胞中被发现，该团队证明细菌及其噬菌体的同源蛋白也能组装成 vault。人工解析这类结构通常需要数周到数月，用 Claude 只花了几天，过程中出现的简单错误由团队与机器学习研究者协作修正。
We’re sharing how our biology research team worked with Claude to map the first 3D structure of a vault particle from bacterial life. Vault particles are a longstanding mystery. They are barrel-shaped objects, among the largest protein structures found in our cells. They were first discovered by Leonard Rome and Nancy Kedersha in 1986, but their function remains unknown. With Claude, we’ve found results that might bring us closer to solving that mystery. Until now, vaults were only known in the cells of complex things like animals and plants. We have shown that similar proteins from bacteria (and the viruses that infect them) can also assemble into vaults. Finding the structures in these simpler forms of life may make it easier to investigate their function in our own cells. For our life sciences team, the project was also a demonstration of the potential (and the limitations) of using AI to accelerate science. In our full piece, we discuss how Claude was able to dramatically speed up some stages—manually determining the vault particle’s structure would have taken weeks to months of painstaking work, but here it took days. We also discuss how Claude made some simple mistakes along the way, and how we collaborated with our machine learning researchers to address them. Read more: anthropic.com/research/inves… 💬 9 🔄 11 ❤️ 86 👀 11077 📊 17 ⚡
